Sickle Cell Disorder and their relation to Geographical location: - Relevance to malaria and comprehensive care programs at local and global level
Sucheta Lakhani*1, Niraj Pandit2, Jitendra D. Lakhani3, Ajay George4
Professor, 1Department of Microbiology, 2Department of Community Medicine, 3Department of Medicine, 4Department of ENT; Smt. B. K. Shah Medical Institute and Research Center, Sumandeep Vidyapeeth, Piparia, Waghodia, Vadodara, Gujarat, India.
Sickle cell disease (SCD) though initially restricted to certain geographical places, now has become a global problem due to migration.1, 2 Epidemiology of SCD is same as malaria, which is considered to be a disease of tropics. World distribution of sickle gene has remained same like that of past and present malaria.3 Sickle gene is thought to be result of mutation to protect local community from death due to plasmodial disease.3 Thus relationship between malaria and genetic disorder like thalassemia, Sickle cell disorder and glucose-6-phosphate dehydrogenase deficiency (G6PD) is example of interaction of gene with environment.3,4,5 Mediterranean region, Africa and Asia which has archives of high malaria prevalence is also native for hemoglobinopathies. Migration and resettlement of communities has made SCD, a global problem which is common in America, Australia and Europe, as well.1