| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 8
| Issue : 1 | Page : 9-13 |
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The effect of vitamin C on toxic metals, antioxidant minerals, oxidative stress, and lipid profile of automobile workers
Chikaodili Nwando Obi-Ezeani1, Chudi Emmanuel Dioka2, Samuel Chukwuemeka Meludu3, Ifeoma Joy Onuora4
1 Department of Chemical Pathology, Chukwuemeka Odumegwu Ojukwu University, Awka, Nigeria
2 Department of Chemical Pathology, Nnamdi Azikiwe University, Nnewi, Nigeria
3 Department of Human Biochemistry, Nnamdi Azikiwe University, Nnewi, Nigeria
4 Department of Chemical Pathology, School of Medical Laboratory Technicians, Iyienu Mission Hospital, Ogidi, Anambra, Nigeria
Correspondence Address:
Dr. Chikaodili Nwando Obi-Ezeani
Department of Chemical Pathology, Chukwuemeka Odumegwu Ojukwu University, Awka, Anambra
Nigeria
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/JIHS.JIHS_12_20
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Context: Automobile workers (AMWs) are exposed to lots of toxic chemicals with associated adverse health consequences. The adverse health effects are mainly attributed to oxidative stress, however, antioxidant vitamins may aid in ameliorating these adverse effects. Aim: The aim of this study was to examine the effect of Vitamin C supplementation on toxic metals, antioxidant minerals, oxidative stress, and lipid profile of AMWs. Settings and Design: Twenty-nine AMWs and 30 controls aged 19–55 years were recruited for this study. Subsequently, 27 AMWs received 500 mg Vitamin C tablets daily for 2 months. Subjects and Methods: Five milliliters of fasting blood samples was collected before intervention and at 1- and 2-month intervals for biochemical analyses. Blood lead (Pb), cadmium (Cd), selenium (Se), and zinc (Zn) were analyzed using atomic absorption spectrophotometer, malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured spectrophotometrically, total cholesterol (TC), high-density lipoprotein (HDL), and triglyceride (TG) were measured enzymatically, whereas MDA/TAC, low-density lipoprotein (LDL), very LDL (VLDL), and non-HDL (nHDL) were calculated. Statistical Analysis: Data were analyzed, and statistical significance was set at P < 0.05. Results: The mean levels of Pb, Cd, MDA, MDA/TAC ratio, TC, LDL, VLDL, TG, and nHDL were significantly higher, whereas Se and Zn were significantly lower in AMWs compared to controls (P < 0.05). After 2 months of supplementation, Pb and TG levels decreased significantly, whereas Se, Zn, and HDL levels increased significantly compared to their values at 1 month and baseline (P < 0.05). MDA, MDA/TAC, TC, LDL, VLDL, and nHDL decreased progressively, whereas TAC level increased progressively from baseline to 2 months of Vitamin C intake (P < 0.05). Conclusion: Vitamin C reduced blood lead and oxidative stress, improved antioxidant defense, and may modulate dyslipidemia and adverse cardiovascular outcomes in AMWs.
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