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Year : 2021  |  Volume : 9  |  Issue : 2  |  Page : 75-80

Hypoglycemic activity of endophytic extract of Senna Alata in STZ-induced diabetic mice model

1 Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Anambra State, Nigeria
2 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria
3 Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Federal University of Oye-Ekiti, Ekiti State, Nigeria

Correspondence Address:
Dr. Ogechukwu Lucy Nwankwo
Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jihs.jihs_25_21

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Background: Senna alata belongs to the Senna family and is known to contain several bioactive constituents that contribute to its therapeutic properties. A variety of medicinal and pharmacological effects have been reported, including antidiabetic, antiasthma, anthelmintic, and antiplasmodium infection effects. Objectives: The goal of the study was to determine whether the extract of S. alata can reduce blood sugar levels in streptozotocin (STZ)-induced diabetic mice. Materials and Methods: S. alata leaves were collected from the Department of Botany, University of Nigeria Nsukka, Nigeria, authenticated, and validated. Phytochemical screening was conducted. Specifically, leaf blades were extracted in 70% ethanol for 3 min, transferred to 500 ml of water for 5 min, then cut into small pieces, and then inoculated onto malt extract agar, and local rice was used to inoculate the fermentation medium. 25 male albino mice of 30–35 g weight, average weight of 30–35 g were used in the study. Streptozotocin (STZ; 65 mg/kg) was injected intravenously to induce type 2 diabetes. Results: The crude extract significantly (P < 0.05) reduced the fasting blood glucose levels in STZ-induced diabetic mice. The two doses (250 and 500 mg/kg) of the ethanol extract and metformin 500 mg/kg caused a significant (P < 0.05) reduction in the fasting blood glucose levels from 0 h to the 10th h of treatment. The extract displayed a dose-related reduction in blood sugar level concerning time. The highest reduction rate was found in 500 mg/kg 409.66 ± 1.92. The fasting blood glucose reduction was dose-dependent. The highest reduction rate was found in 500 mg/kg 80.00 ± 4.00 (80.47%) being the highest dose so far. There was a reduction in the bodyweight of the animals induced with STZ. Conclusion: The endophytic extract of S. alata displayed useful pharmacological properties and can be used to manage diabetes and its complications.

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